Accepted Speakers
Oscar Abilez | Stanford |
Mo Ebrahimkhani | University of Pittsburgh |
Zev Gartner | University of California San Francisco |
Linda Griffith | MIT |
Thomas Hartung | John Hopkins Bloomberg School of Public Health |
Kimberly Homan | Genentech |
Tracy Hookway | Binghamton University |
Valerie Horsley | Yale |
Christopher Hughes | UC Irvine |
Melissa Lambeth Kemp | Georgia Tech |
Jennifer Lewis | Harvard |
Leonardo Morsut | University of Southern California |
Alysson Muotri | UCSD |
Manu Platt | NIH-NIBIB |
Milica Radisic | University of Toronto |
Ritu Raman | MIT |
Ankur Singh | Georgia Tech |
Mark Skyler-Scott | Stanford Medicine |
Shuichi Takayama | Georgia Institute of Technology and Emory University |
Takanori Takebe | Cincinnati Children’s Hospital |
Gordana Vunjak-Novakovic | Columbia University |
Joseph Wu | Stanford |
Oscar Abilez
Senior Scientist at Stanford University and Co-Founder and President of Bullseye Biotechnologies, Inc.
Oscar Abilez is a Senior Scientist at Stanford University and Co-Founder of Bullseye Biotechnologies. His work combines human pluripotent stem cells (hPSCs), developmental biology, and tissue/organoid engineering to model and control the earliest stages of cardiac development and vascularization. He previously trained in surgery at Stanford where he also received his PhD in bioengineering. He received his MD from Cornell University and BS in Mechanical Engineering from UT-Austin.
Mo Ebrahimkhani
Modeling the Black Box of Human Development to Advance Regenerative Medicine (ABSTRACT)
Thursday, March 27th | 11:30 – 12:00
Bio coming soon.
Zev Gartner
Directing the self-organization of more complex and reproducible 3D tissue models (ABSTRACT)
Wednesday, March 26th | 10:15 – 10:45
Zev Gartner is a Professor in the Department of Pharmaceutical Chemistry at the University of California, San Francisco. His lab’s research focuses on understanding the self-organization, maintenance, and breakdown of tissue structure. The lab’s long term goal is to leverage this understanding to guide the formation of complex human tissues and organs from simpler building blocks. Professor Gartner received his B.S. in Chemistry from UC Berkeley in 1999 and his Ph.D. in Chemical Biology in 2004 with David Liu at Harvard University. In 2005 he completed postdoctoral training with Professor Carolyn Bertozzi at UC Berkeley. He has been honored with awards including the Kimmel Scholar award, the NIH New Innovator Award, and the Era of Hope Award from the Department of Defense Breast Cancer Research Program. He co-directs the NSF Center for Cellular Construction, has been named one of Popular Science’s ‘Brilliant 10,’ and is a Chan Zuckerberg Biohub Investigator.
Linda Griffith
Linda Griffith is currently the School of Engineering Professor of Teaching Innovation in Biological Engineering at the Massachusetts Institute of Technology, where she also directs the Center for Gynepathology Research She received her BS in from Georgia Tech (1982) and her PhD from UC Berkeley (1988), both in Chemical Engineering. Her current research focuses on building living patient avatars to model chronic inflammatory diseases, especially those that preferentially afflict women, and she works closely with clinicians and industry partners. . She is a member of the National Academy of Engineering, the National Academy of Medicine, the National Academy of Inventors, the American Academy of Arts and Sciences, a MacArthur Foundation Fellow, and has received numerous other awards from professional societies and from MIT. She serves on the advisory board of the Society for Women’s Health Research and has served on the advisory committee to the director of the National Institutes of Health. She is a founding member of MIT’s Biological Engineering Department and is recognized at MIT as a MacVicar Fellow, awarded for excellence in undergraduate education.
Thomas Hartung
AI + brain organoids = Organoid Intelligence (OI) (ABSTRACT)
Wednesday, March 26th | 11:00 – 11:30
Understanding brain function remains challenging as work with human and animal models is complicated by compensatory mechanisms, while in vitro models have been too simple until now. With the advent of human stem cells and the bioengineering of brain microphysiological systems (MPS), understanding how both cognition and long-term memory arise is now coming into reach. We suggest combining cutting-edge AI with MPS research to spearhead organoid intelligence (OI) as synthetic biological intelligence. The vision is to realize cognitive functions in brain MPS and scale them to achieve relevant short- and long-term memory capabilities and basic information processing as the ultimate functional experimental models for neurodevelopment and neurological function and as cell-based assays for drug and chemical testing. By advancing the frontiers of biological computing, we aim to (a) create models of intelligence-in-a-dish to study the basis of human cognitive functions, (b) provide models to advance the search for toxicants contributing to neurological diseases and identify remedies for neurological maladies, and (c) achieve relevant biological computational capacities to complement traditional computing. Increased understanding of brain functionality, in some respects still superior to today’s supercomputers, may allow to imitate this in neuromorphic computer architectures or might even open up biological computing to complement silicon computers. At the same time, this raises ethical questions such as where sentience and consciousness start and what the relationship between a stem cell donor and the respective OI system is. Such ethical discussions will be critical for the socially acceptable advance of brain organoid models of cognition. Based on the Baltimore Declaration Toward Exploring Organoid Intelligence, a community is forming to realize this vision.
Kimberly Homan
The Route from Development to Deployment of M-CELS for Drug Development (ABSTRACT)
Thursday, March 27th | 9:00 – 9:45
Kim is a Sr. Director and Distinguished Scientist at Genentech and she runs the Complex in vitro Systems lab, a core group focused on employing new predictive tools to enhance clinical translational outcomes. She has prior experience holding key leadership positions in two biotech startups, one of which she co-founded while in graduate school at UT Austin. Prior to that, as a co-appointed postdoc at Roche and at the Wyss Institute in Harvard, Kim invented methods to bioprint human tissues and use them to model drug disposition, mode of action, and safety. Kim holds a B.S. degree in chemical engineering and Ph.D. in biomedical engineering; she is also a former United States Marine Corps officer and veteran.
Tracy Hookway
Bio coming soon.
Valerie Horsley
Mechanical regulation of tissue fibrosis
Thursday, March 27th | 9:45 – 10:15
Valerie Horsley, PhD, leads a laboratory team focused on how tissues develop, repair, and develop pathologies associated with human disease. Her lab uses human clinical samples, mouse genetics, genomic technology, and in vitro cell biology assays to study epithelial development, repair, and homeostasis with a primary focus on the skin. Her laboratory team is working to understand how stromal cells communicate to promote skin repair and ameliorate disease.
Christopher C.W. Hughes
Chancellor’s Professor of Molecular Biology & Biochemistry, and Biomedical Engineering
Associate Dean for Research and Innovation
School of Biological Sciences
UC Irvine
Professor Hughes’ research focuses on the development and growth of blood vessels, and spans multiple scales – from understanding the basic molecular mechanisms of angiogenesis, to engineering of artificial tissues. Recently his lab has been pioneering “Body-on-Chip” technology, which allows for micro-organs to be grown on a “chip”, each with its own blood vessel network. Tissues generated include liver, pancreas, lung, various tumors and brain, including a blood-brain barrier. These devices are gaining use as screening tools for new therapeutic drugs, and the technology is now licensed to Aracari Biosciences, for which Dr. Hughes is a founder and CSO. Professor Hughes has published over 130 peer-reviewed manuscripts, and in 2014 was elected a Fellow of the American Association for the Advancement of Science (AAAS).
Melissa Lambeth Kemp
Quantifying and simulating spatial organization in iPSC-derived tissues
Wednesday, March 26th | 1:45 – 2:15
Carol Ann & David D. Flanagan Professor
Wallace H. Coulter Department of Biomedical Engineering
Georgia Institute of Technology & Emory University
Melissa Lambeth Kemp, Ph.D. is the Carol Ann & David D. Flanagan Endowed Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, where she has been a member of the faculty since 2006. Her research focuses on the development of computational systems biology models to investigate modes of communication that drive multicellular spatial organization for cancer and regenerative medicine applications. Dr. Kemp is currently the research director of a multi-institutional NSF Engineering Research Center in Cell Manufacturing Technologies and is the former co-chair of the NCI Cancer Systems Biology Consortium. Dr. Kemp’s career honors include Georgia Cancer Coalition Distinguished Scholar and NIH New Innovator.
Jennifer A. Lewis
Jennifer A. Lewis is the Jianmin Yu Professor of Arts and Sciences, the Wyss Professor for Biologically Inspired Engineering in the Paulson School of Engineering and Applied Sciences, a core faculty member of the Wyss Institute, Bioengineering Chair and Director of the NSF MRSEC at Harvard University. Her research focuses on biomanufacturing vascularized human organoids and tissues for drug testing, disease modeling, and therapeutic use. Multiple startups are commercializing technology from her lab ranging from drug delivery and kidney therapeutics. She is an elected member of the National Academy of Sciences, National Academy of Engineering, National Academy of Inventors, and the American Academy of Arts and Sciences and has received numerous awards for her work.
Leonardo Morsut
Bio coming soon.
Alysson R. Muotri
Modeling human neurodevelopment using brain organoids (ABSTRACT)
Friday March 28th | 9:00 – 9:45
Professor of Cellular & Molecular Medicine, University of California San Diego, School of Medicine
Dr. Muotri is a professor at the Departments of Pediatrics and Cellular & Molecular Medicine at UC San Diego. He is also the Director of the Sanford Stem Cell Education and Integrated Space Stem Cell Orbital Research (ISSCOR), the Director of the Archealization Center (ArchC), and Associate Director for the Center for Academic Research & Training in Antropogeny (CARTA). Dr. Muotri earned a BSc in Biological Sciences from the State University of Campinas in 1995 and a Ph.D. in Genetics in 2001 from the University of Sao Paulo, Brazil. He moved to the Salk Institute as Pew Latin America Fellow in 2002 for postdoctoral training in the fields of neuroscience and stem cell biology. His research focuses on brain evolution and modeling neurological diseases using human induced pluripotent stem cells and brain organoids. He has received several awards, including the prestigious NIH Director’s New Innovator Award, NARSAD, Emerald Foundation Young Investigator Award, Surugadai Award, Rock Star of Innovation, NIH EUREKA Award, two Telly Awards for Excellence in Science Communication, among several others.
Manu Platt
Dr. Manu Platt became the inaugural director of the NIH-wide Center for Biomedical Engineering Technology Acceleration (BETA Center) housed within NIBIB, as a new NIH campus model for accelerating technology-driven interdisciplinary research and clinical translation and to bring engineering, clinicians, and basic scientists together in February 2023. Dr. Manu Platt earned his B.S. in Biology from Morehouse College and Ph.D. from Georgia Tech/Emory in Biomedical Engineering. After a postdoc at MIT, he returned to Georgia Tech/Emory’s joint department as an Assistant Professor where he worked up to promotion to full Professor. His research program focuses on proteolytic mechanisms of disease, translational approaches to reduce strokes in people affected by sickle cell disease, and harnessing proteolytic networks and systems biology tools to predict disease progression. Among other awards, Dr. Platt was awarded the Biomedical Engineering Society Diversity Award, is a Fellow of American Institute for Medical and Biological Engineering (AIMBE), Fellow of Biomedical Engineering Society, the Root 100 in 2019, and AAAS Mentor Award in 2021.
Milica Radisic
Dr. Milica Radisic is a Professor at the University of Toronto, Tier 1 Canada Research Chair in Organ-on-a-Chip Engineering and a Senior Scientist at the Toronto General Research Institute. She is also Director of the NSERC CREATE Training Program in Organ-on-a-Chip Engineering & Entrepreneurship and a co-lead for the Center for Research and Applications in Fluidic Technologies. She is a Fellow of the Royal Society of Canada-Academy of Science, Canadian Academy of Engineering, the American Institute for Medical & Biological Engineering, Tissue Engineering & Regenerative Medicine Society as well as Biomedical Engineering Society. She was a recipient of the MIT Technology Review Top 35 Under 35, Queen Elizabeth II Diamond Jubilee Medal, NSERC E.W.R Steacie Fellowship, YWCA Woman of Distinction Award, Killam Fellowship, Acta Biomaterialia Silver Medal, and Humboldt Research Award to name a few. Her research focuses on organ-on-a-chip engineering and development of new biomaterials that promote healing and attenuate scarring. She developed new methods to mature iPSC derived cardiac tissues using electrical stimulation. She is an Executive Editor for ACS Biomaterials Science & Engineering, Senior Consulting Editor for the Journal of Molecular and Cellular Cardiology, a reviewing editor for eLife and a member of the editorial board of another 8 journals. She served on the Board of Directors for Ontario Society of Professional Engineers, Canadian Biomaterials Society and McMaster University Alumni Association. She organized Keystone, EMBO and ECI conferences and numerous sessions at TERMIS and BMES meetings. She served as a Scientific Officer for the Canadian Institutes of Health Research and member of review panels for CIHR, NIH and Israel Ministry of Education. She is the Chair of Investment Committee for Serbia Innovation Fund. She is a co-founder of two companies TARA Biosystems (acquired by Valo Health), that uses human engineered heart tissues in drug development and safety testing, and Quthero that advances regenerative hydrogels. Her work has been presented in over 260 publications, garnering over 23,000 citations with an h-index of 74. Her publications appeared in Cell, Nature Materials, Nature Methods, Nature Protocols, Nature Communications, PNAS etc.
Ritu Raman
Tissue Engineering Multicellular Models of the Motor Control System for Medicine and Machines (ABSTRACT)
Friday March 28th | 9:45 – 10:15
Eugene Bell Career Development Assistant Professor of Tissue Engineering
Department of Mechanical Engineering, Massachusetts Institute of Technology
Ritu Raman, PhD is the Eugene Bell Career Development Assistant Professor of Mechanical Engineering at MIT. Her lab is centered on 4D tissue engineering of biological actuators for applications in medicine and machines. Ritu’s research has received several recognitions including the NSF CAREER Award, the Army Research Office YIP Award, and the Office of Naval Research YIP Award. She is also the recipient of the Spira Award for Excellence in Teaching at MIT and the author of the MIT Press book Biofabrication. Ritu received her BS from Cornell University and her PhD as an NSF Fellow at the University of Illinois at Urbana-Champaign. She completed her postdoctoral research as a L’Oreal For Women in Science Fellow and NASEM Ford Foundation Fellow with Prof. Robert Langer at MIT. RamanLab@mit.edu | @DrRituRaman
Ankur Singh
Human immune organoids and immune-on-chip to decode immunity in healthy donors and cancer patients (ABSTRACT)
Friday March 28th | 11:15 – 11:45
Ankur Singh is a Carl Ring Family Professor in George W. Woodru7 School of Mechanical Engineering at Georgia Institute of Technology with a joint appointment in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. At Georgia Tech, he serves as the Director of the Center for Immunoengineering. Before Georgia Tech, he was a tenured Associate Professor at Cornell University. He is a Fellow of the American Institute for Medical and Biological Engineering. His laboratory develops human immune organoids and enabling technologies to understand healthy and diseased
immune cells and translate therapeutics. He has received funding from the National Institute of Health, National Science Foundation, Wellcome Leap HOPE, Department of Defense, Defense Threat Reduction Agency, the Curci Foundation, and Lymphoma and Leukemia Society. He has published >70 articles in peer-reviewed journals, including Nature Methods, Nature Materials, Nature Nanotechnology, Nature Immunology, Nature Communications, Nature Reviews Materials, Nature Protocols, Science Advances, Cell Reports, PNAS, Blood, and Advanced Materials. He has written multiple editorials for Science Translational Medicine. He is a recipient of the NSF CAREER, Society for Biomaterials Mid Career Award, Society for Biomaterials Young Investigator Award, CMBE
Young Innovator Award, CMBE Rising Star Award, 3M Faculty Award, DoD Career award, Georgia Tech CIOS Teaching Award, Cornell’s Teaching Excellence Award, and Cornell’s Research Excellence Award. His first generation immune organoids were identified among the Top 100 Discoveries of 2015 by Discover Magazine. He is the Founder and past Chair of the Immune Engineering SIG at the Society for Biomaterials and Controlled Release Society. He currently serves as the Associate Editor for Science Advances, Biomaterials, and Cellular and Molecular Bioengineering.
Mark A. Skyler-Scott
Assistant Professor, Bioengineering
Basic Science and Engineering (BASE) Initiative at the Betty Irene Moore Children’s Heart Center
Mark Skylar-Scott is an Assistant Professor of Bioengineering at Stanford, a member of the Basic Science and Engineering Initiative at the Children’s Heart Center and a Chan-Zuckerberg Biohub Investigator. His laboratory focuses on the scaling-up of 3D bioprinting technologies with applications in cardiac tissue engineering to cure congenital heart defects. His approaches emphasize scaling stem cell production and differentiation and tissue vascularization and maturation to bring tissue engineering from microscopic tissues in the Petri dish towards kilograms of viable and functional organs. He has received the NIH Director’s New Innovator Award and an ARPA-H Award to support the development of new 3D printing hardware, wetware, and software to accelerate cardiovascular tissue engineering.
Shuichi Takayama
Professor, Georgia Research Alliance Eminent Scholar, and
Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine
Wallace H. Coulter Department of Biomedical Engineering at
Georgia Institute of Technology & Emory University School of Medicine
Krone Engineering Biosystems Building (EBB) 4018, 950 Atlantic Drive NW, Atlanta, Georgia 30332
B.S.& M.S., 1986-1994, Agricultural Chemistry, University of Tokyo
Ph.D., 1994-1998, Scripps Research Institute, Chemistry
Postdoc 1998-2000 Harvard University, Chemistry and Chemical Biology
Prof. Shuichi Takayama’s research interests started with bioorganic synthesis at the University of Tokyo and Scripps Research Institute. Subsequently he pursued postdoctoral studies in bioengineered microsystems at Harvard University as a Leukemia and Lymphoma Society Fellow. He spent 17 years at the University of Michigan in the Biomedical Engineering Department and Macromolecular Science and Engineering Program, then moved to the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory School of Medicine in the summer of 2017. He is an associate editor of Integrative Biology and recipient of the Pioneers of Miniaturization Prize. He is also the Director of the Nakatani RIES Program which promotes international undergraduate student internships between the US and Japan.
Takanori Takebe
Organoid-guided Precision Hepatology (ABSTRACT)
Wednesday, March 26th | 11:00 – 11:30
Professor Takanori Takebe, MD PhD is an Endowed Chair of Organoid Medicine, Division of Gastroenterology, Hepatology and Nutrition, and Director of Commercial Innovation for Center for Stem Cell and Organoid Medicine (CuSTOM) at Cincinnati Children’s Hospital Medical Center, and a Professor at Osaka University. His lab seeks to develop and apply novel approaches and tools to recapitulate, probe and manipulate human liver development and to understand the personalized molecular mechanisms that lead to disease. Towards this goal, he is building experimental organogenesis approaches to engineer hepato-pancreato-biliary systems using pluripotent stem cells in vitro and in animals to construct and deconstruct previously inaccessible phases of human liver health and disease. He is on the board of directors for the International Society for Stem Cell Research.
Gordana Vunjak-Novakovic
Patient-specific Organs-on-Chip models of human pathophysiology (ABSTRACT)
Thursday, March 27th | 2:00 – 2:45
University Professor, Columbia University
Gordana Vunjak-Novakovic is University Professor, the first engineer to receive this highest academic rank at Columbia University. The focus of her lab is on engineering functional human tissues for use in regenerative medicine and patient-specific “organs-on-a-chip” models of disease. She is well published and highly cited, has mentored over 250 trainees, and her lab has launched five biotech companies. She received numerous awards and was elected to nine national and international academies including the Academia Europaea, US National Academies of Engineering, Medicine and Inventors, Royal Society Academy of Science, and the American Academy of Arts and Sciences.
Joseph Wu
Stem Cells & Genomics: From Precision Medicine to Clinical Trials in Dish
Thursday, March 27th | 3:45 – 4:15
Bio coming soon.